Prognostic factors in the progression of intervertebral disc degeneration: Which patient should be targeted with regenerative therapies?

ABSTRACT:

Objective

Possible regenerative treatments for lumbar intervertebral disc degeneration (DD) are rapidly emerging. There is consensus that the patient that would benefit most has early-stage DD, with a predicted deterioration in the near future. To identify this patient, the aim of this study was to identify prognostic factors for progression of DD.

Study design

Systematic review.

Methods

A systematic search was performed on studies evaluating one or more prognostic factor(s) in the progression of DD. The criteria for inclusion were (a) patients diagnosed with DD on MRI, (b) progression of DD at follow-up, and (c) reporting of one or more prognostic factor(s) in progression of DD. Two authors independently assessed the methodological quality of the included studies. Du

SUBMITTER: Rustenburg CME 

PROVIDER: S-EPMC6764790 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature