Understanding optical reflectance contrast for real-time characterization of epithelial precursor lesions.

ABSTRACT: Detecting early-stage epithelial cancers and their precursor lesions are challenging as lesions could be subtle and focally or heterogeneously distributed over large mucosal areas. Optical coherence tomography (OCT) that enables wide-field imaging of subsurface microstructures in vivo is a promising screening tool for epithelial diseases. However, its diagnostic capability has not been fully appreciated since the optical reflectance contrast is poorly understood. We investigated the back-scattered intensities from clustered or packed nanometer scale intracellular scatterers using finite-difference time-domain method and 1-μm resolution form of OCT, and uncovered that there existed correlations between the reflectance contrasts and the ultrastructural clustering or packing states of these s

SUBMITTER: Chen S 

PROVIDER: S-EPMC6764805 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature