Saliva MicroRNA Differentiates Children With Autism From Peers With Typical and Atypical Development.

ABSTRACT:

Objective

Clinical diagnosis of autism spectrum disorder (ASD) relies on time-consuming subjective assessments. The primary purpose of this study was to investigate the utility of salivary microRNAs for differentiating children with ASD from peers with typical development (TD) and non-autism developmental delay (DD). The secondary purpose was to explore microRNA patterns among ASD phenotypes.

Method

This multicenter, prospective, case-control study enrolled 443 children (2-6 years old). ASD diagnoses were based on DSM-5 criteria. Children with ASD or DD were assessed with the Autism Diagnostic Observation Schedule II and Vineland Adaptive Behavior Scales II. MicroRNAs were measured with high-throughput sequencing. Differential expression of microRNAs was compared among the A

SUBMITTER: Hicks SD 

PROVIDER: S-EPMC6764899 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature