Targeting neuroinflammation with minocycline in heavy drinkers.

ABSTRACT:

Rationale

Alcohol has both acute and chronic effects on neuroimmune signaling, including triggering pro-inflammatory cytokine release by microglia. Minocycline, a second-generation tetracycline antibiotic, inhibits microglial activation and reduces neuroinflammation in preclinical studies. In mice, minocycline also reduces ethanol intake, attenuates ethanol-induced conditioned place preference, and inhibits ethanol-induced microglial activation and pro-inflammatory cytokine release.

Objective

Here, for the first time, we tested the effects of minocycline on subjective response to ethanol and acute ethanol-induced inflammation in humans.

Methods

Forty-eight heavy drinkers participated in a double-blind, placebo-controlled trial in which they were randomized to receive

SUBMITTER: Petrakis IL 

PROVIDER: S-EPMC6764907 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature