Manipulating energy migration within single lanthanide activator for switchable upconversion emissions towards bidirectional photoactivation.

ABSTRACT: Reliance on low tissue penetrating UV or visible light limits clinical applicability of phototherapy, necessitating use of deep tissue penetrating near-infrared (NIR) to visible light transducers like upconversion nanoparticles (UCNPs). While typical UCNPs produce multiple simultaneous emissions for unidirectional control of biological processes, programmable control requires orthogonal non-overlapping light emissions. These can be obtained through doping nanocrystals with multiple activator ions. However, this requires tedious synthesis and produces complicated multi-shell nanoparticles with a lack of control over emission profiles due to activator crosstalk. Herein, we explore cross-relaxation (CR), a non-radiative recombination pathway typically perceived as deleterious, to manipulate e

SUBMITTER: Mei Q 

PROVIDER: S-EPMC6764961 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature