Effect of Melatonin on Blood Loss After Cesarean Section: A Prospective Randomized Double-Blind Trial.

ABSTRACT:

Background and objectives

The similarities between the melatonin and oxytocin signaling could lead to increased contractility of myometrium. We designed this randomized double-blind, placebo-controlled trial to evaluate the efficacy of melatonin in reduction of blood loss during and after the lower segment cesarean section.

Methods

One hundred and twenty patients who had been scheduled for cesarean section under spinal anesthesia were enrolled in the study. We randomly allocated them to one of the three following groups to receive either melatonin 3 mg (M₃), melatonin 6 mg (M₆), or placebo (P) sublingually 20 min before the surgery. The hemoglobin levels before and 12 h after surgery, the mean weight of the materials used in the operation time, the need

SUBMITTER: Khezri MB 

PROVIDER: S-EPMC6765044 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature