Circulating extracellular RNAs, myocardial remodeling, and heart failure in patients with acute coronary syndrome.

ABSTRACT:

Background

Given high on-treatment mortality in heart failure (HF), identifying molecular pathways that underlie adverse cardiac remodeling may offer novel biomarkers and therapeutic avenues. Circulating extracellular RNAs (ex-RNAs) regulate important biological processes and are emerging as biomarkers of disease, but less is known about their role in the acute setting, particularly in the setting of HF.

Methods

We examined the ex-RNA profiles of 296 acute coronary syndrome (ACS) survivors enrolled in the Transitions, Risks, and Actions in Coronary Events Center for Outcomes Research and Education Cohort. We measured 374 ex-RNAs selected a priori, based on previous findings from a large population study. We employed a two-step, mechanism-driven approach to identify ex

SUBMITTER: Tran KV 

PROVIDER: S-EPMC6765153 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature