Downregulation of homeodomain protein Cut is essential for Drosophila follicle maturation and ovulation.

ABSTRACT: Proper development and maturation of a follicle is essential for successful ovulation and reproduction; however, the molecular mechanisms for follicle maturation, particularly for somatic follicle cell differentiation, are poorly understood. During Drosophila oogenesis, the somatic follicle cells encasing oocytes undergo two distinct well-established transitions: the mitotic to endocycle switch at stage 6/7 and the endocycle to gene amplification switch at stage10A/10B. Here, we identify a novel third follicle cell transition that occurs in the final stages of oogenesis (stage 13/14). This late follicle cell transition is characterized by upregulation of the transcription factor Hindsight (Hnt), and downregulation of the homeodomain transcription factor Cut and the zinc-finger trans

SUBMITTER: Knapp EM 

PROVIDER: S-EPMC6765176 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature