Quantifying the contribution of sequence variants with regulatory and evolutionary significance to 34 bovine complex traits.

ABSTRACT: Many genome variants shaping mammalian phenotype are hypothesized to regulate gene transcription and/or to be under selection. However, most of the evidence to support this hypothesis comes from human studies. Systematic evidence for regulatory and evolutionary signals contributing to complex traits in a different mammalian model is needed. Sequence variants associated with gene expression (expression quantitative trait loci [eQTLs]) and concentration of metabolites (metabolic quantitative trait loci [mQTLs]) and under histone-modification marks in several tissues were discovered from multiomics data of over 400 cattle. Variants under selection and evolutionary constraint were identified using genome databases of multiple species. These analyses defined 30 sets of variants, and for each se

SUBMITTER: Xiang R 

PROVIDER: S-EPMC6765237 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature