Large-scale identification of pathogen essential genes during coinfection with sympatric and allopatric microbes.

ABSTRACT: Recent evidence suggests that the genes an organism needs to survive in an environment drastically differ when alone or in a community. However, it is not known if there are universal functions that enable microbes to persist in a community and if there are functions specific to interactions between microbes native to the same (sympatric) or different (allopatric) environments. Here, we ask how the essential functions of the oral pathogen Aggregatibacter actinomycetemcomitans change during pairwise coinfection in a murine abscess with each of 15 microbes commonly found in the oral cavity and 10 microbes that are not. A. actinomycetemcomitans was more abundant when coinfected with allopatric than with sympatric microbes, and this increased fitness correlated with expanded meta

SUBMITTER: Lewin GR 

PROVIDER: S-EPMC6765283 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature