Genetic predictors of chemotherapy-related amenorrhea in women with breast cancer.

ABSTRACT:

Objective

To study how genetics may play a role in determining risk of chemotherapy-related amenorrhea (CRA) in young women with breast cancer.

Design

Genome-wide association study.

Setting

Not applicable.

Patient(s)

Premenopausal women ≤45 years of age enrolled in one of these three trials were included if they had at least one menstrual case report form after chemotherapy ended and if they were of European ancestry. Forms during and up to 3 months after receipt of GnRH agonist were excluded.

Intervention(s)

None.

Main outcome measure(s)

The association of single-nucleotide polymorphisms with post-chemotherapy menstruation adjusted for trial and arm, age, tamoxifen use, and nodal status.

Result(s)

The median age of the 1,168 women was 41 y

SUBMITTER: Ruddy KJ 

PROVIDER: S-EPMC6765404 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature