Diffusion MRI microstructural models in the cervical spinal cord - Application, normative values, and correlations with histological analysis.

ABSTRACT: Multi-compartment tissue modeling using diffusion magnetic resonance imaging has proven valuable in the brain, offering novel indices sensitive to the tissue microstructural environment in vivo on clinical MRI scanners. However, application, characterization, and validation of these models in the spinal cord remain relatively under-studied. In this study, we apply a diffusion "signal" model (diffusion tensor imaging, DTI) and two commonly implemented "microstructural" models (neurite orientation dispersion and density imaging, NODDI; spherical mean technique, SMT) in the human cervical spinal cord of twenty-one healthy controls. We first provide normative values of DTI, SMT, and NODDI indices in a number of white matter ascending and descending pathways, as well as various gray matter regi

SUBMITTER: Schilling KG 

PROVIDER: S-EPMC6765439 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature