Modeling Regional Transmission and Containment of a Healthcare-associated Multidrug-resistant Organism.

ABSTRACT:

Background

The Centers for Disease Control and Prevention (CDC) recently published interim guidance for a public health response to contain novel or targeted multidrug-resistant organisms (MDROs). We assessed the impact of implementing the strategy in a US state using a mathematical model.

Methods

We used a deterministic compartmental model, parametrized via a novel analysis of carbapenem-resistant Enterobacteriaceae data reported to the National Healthcare Safety Network and patient transfer data from the Centers for Medicare and Medicaid Services. The simulations assumed that after the importation of the MDRO and its initial detection by clinical culture at an index hospital, fortnightly prevalence surveys for colonization and additional infection control interventions wer

SUBMITTER: Paul P 

PROVIDER: S-EPMC6765447 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature