Executive dysfunction in depression in adolescence: the role of inflammation and higher body mass.

ABSTRACT:

Background

There is substantial evidence that many depressed individuals experience impaired executive functioning. Understanding the causes of executive dysfunction in depression is clinically important because cognitive impairment is a substantial contributor to functional impairment. This study investigated whether elevated levels of an inflammatory cytokine [interleukin-6 (IL-6)] and/or higher body mass index (BMI) concurrently and/or prospectively accounted for the relationship between depressive symptoms and impaired executive functioning in adolescents.

Methods

A diverse, community sample of adolescents (N = 288; mean age = 16.33; 51.4% female; 59.0% African-American) completed assessments of height and weight, IL-6, depressive symptoms, and self-report/behavioral mea

SUBMITTER: Mac Giollabhui N 

PROVIDER: S-EPMC6765453 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature