[Postpartum depression: association with genetic polymorphisms of noradrenaline metabolic enzymes and the risk factors].

ABSTRACT: OBJECTIVE:To investigate the association of genetic polymorphisms of norepinephrine metabolizing enzymes with postpartum depression and analyze the risk factors for postpartum depression in women following cesarean section. METHODS:A total of 591 Chinese woman of Han Nationality undergoing caesarean section were enrolled in this study. The diagnosis of postpartum depression was established for an Edinburgh Postnatal Depression Scale (EPDS) score ≥9. For all the women without antepartum depression, the genotypes of catechol-O-methyltransferase (COMT; at 5 sites including rs2020917 and rs737865) and monoamine oxidase A (rs6323) were determined using Sequenom? Mass Array single nucleotide polymorphism (SNP) analysis. We analyzed the contribution of the genetic factors (SNPs, linkage disequili

SUBMITTER: Ma J 

PROVIDER: S-EPMC6765576 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature