The Growth Hormone Releasing Hormone Analogue, Tesamorelin, Decreases Muscle Fat and Increases Muscle Area in Adults with HIV.

ABSTRACT:

Background

Tesamorelin, a growth hormone-releasing hormone analogue, decreases visceral adipose tissue in people living with HIV, however, the effects on skeletal muscle fat and area are unknown.

Objectives

The goals of this exploratory secondary analysis were to determine the effects of tesamorelin on muscle quality (density) and quantity (area).

Design

Secondary, exploratory analysis of two previously completed randomized (2:1), clinical trials.

Setting

U.S. and Canadian sites.

Participants

People living with HIV and with abdominal obesity. Tesamorelin participants were restricted to responders (visceral adipose tissue decrease ≥8%).

Intervention

Tesamorelin or placebo.

Measurements

Computed tomography scans (at L4-L5) were used to quanti

SUBMITTER: Adrian S 

PROVIDER: S-EPMC6766405 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature