Metabolic adaptation is not observed after 8 weeks of overfeeding but energy expenditure variability is associated with weight recovery.

ABSTRACT:

Background

A metabolic adaptation, defined as an increase in energy expenditure (EE) beyond what is expected with weight gain during overfeeding (OF), has been reported but also refuted. Much of the inconsistency stems from the difficulty in conducting large, well-controlled OF studies in humans.

Objectives

The primary aim of this study was to determine whether a metabolic adaptation to OF exists and if so, attenuates weight gain.

Methods

Thirty-five young adults consumed 40% above their baseline energy requirements for 8 wk, and sleeping metabolic rate (SMR) and 24-h sedentary energy expenditure (24h-EE) were measured before and after OF. Subjects were asked to return for a 6-mo post-OF follow-up visit to measure body weight, body composition, and physical activity.<

SUBMITTER: Johannsen DL 

PROVIDER: S-EPMC6766445 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature