Heritability and complex segregation analysis of diabetes mellitus in American Eskimo Dogs.

ABSTRACT:

Background

Heritability and mode of inheritance of spontaneous diabetes mellitus (DM) in American Eskimo Dogs (AED) are unknown.

Objective

Investigate the heritability and mode of inheritance of DM in AED.

Animals

An extended family of AED including 71 AED without DM, 47 AED with an unknown phenotype, and 38 AED with spontaneous DM.

Methods

Retrospective evaluation of inheritance. A logistic regression model was formulated to evaluate the heritability of DM, including effects of sex and neuter status. Subsequently, complex segregation analysis was employed to investigate the inheritance pattern of DM in AED. Six plausible models were considered, and the Akaike Information Criterion was used to determine the best of the biologically feasible models of inheritanc

SUBMITTER: Cai SV 

PROVIDER: S-EPMC6766479 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature