Retrospective evaluation of cyclosporine in the treatment of presumed idiopathic chronic hepatitis in dogs.

ABSTRACT:

Background

The etiology of idiopathic chronic hepatitis (ICH) in dogs is poorly understood, but evidence supports an immune-mediated pathogenesis in some dogs.

Objectives

To describe a case series of dogs with presumed ICH treated with cyclosporine (CsA) with or without concurrent medications and to document the incidence of biochemical remission and factors associated with failure to attain remission.

Animals

Forty-eight client-owned dogs diagnosed with presumed ICH, treatment of which included CsA.

Methods

Two-institution, retrospective case series of dogs between 2010 and 2017. All dogs were treated with CsA with or without concurrent medications for ≥2 weeks. Data were collected from medical records.

Results

Biochemical remission (<1.1 times the uppe

SUBMITTER: Ullal T 

PROVIDER: S-EPMC6766481 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature