Perivascular CD73⁺ cells attenuate inflammation and interstitial fibrosis in the kidney microenvironment.

ABSTRACT: Progressive tubulointerstitial fibrosis may occur after acute kidney injury due to persistent inflammation. Purinergic signaling by 5'-ectonucleotidase, CD73, an enzyme that converts AMP to adenosine on the extracellular surface, can suppress inflammation. The role of CD73 in progressive kidney fibrosis has not been elucidated. We evaluated the effect of deletion of CD73 from kidney perivascular cells (including pericytes and/or fibroblasts of the Foxd1⁺ lineage) on fibrosis. Perivascular cell expression of CD73 was necessary to suppress inflammation and prevent kidney fibrosis in Foxd1CreCD73^fl/fl mice evaluated 14 days after unilateral ischemia-reperfusion injury or folic acid treatment (250 mg/kg). Kidneys of Foxd1CreCD73^fl/fl mice had grea

SUBMITTER: Perry HM 

PROVIDER: S-EPMC6766625 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature