Urine complement activation fragments are increased in patients with kidney injury after cardiac surgery.

ABSTRACT: Experiments in mouse models have shown that the complement cascade is activated within the kidney after ischemia-reperfusion and that complement activation contributes to tubular injury in this setting. Less is known, however, about complement activation in human kidneys after ischemia or whether complement activation in the tubulointerstitium can be detected by measurement of complement fragments in the urine. We hypothesized that urine biomarkers of complement activation would rapidly increase in patients who develop ischemic acute kidney injury, signaling complement activation within the kidney. We confirmed that the alternative pathway of complement is activated in the kidneys of mice after ischemia-reperfusion, and we found that levels of factor B fragments (generated during alternati

SUBMITTER: Laskowski J 

PROVIDER: S-EPMC6766629 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature