AhR-ROR-γt complex is a therapeutic target for MAP4K3/GLK^highIL-17A^high subpopulation of systemic lupus erythematosus.

ABSTRACT: The cytokine IL-17A plays critical roles in the pathogenesis of autoimmune diseases. The frequencies of MAP kinase kinase kinase kinase 3 [also named germinal center kinase-like kinase (GLK)]-overexpressing T cells are correlated with disease severity of systemic lupus erythematosus (SLE). T-cell-specific GLK-transgenic mice develop spontaneous autoimmune responses through IL-17A. GLK signaling selectively stimulates IL-17A production in murine T cells through inducing aryl hydrocarbon receptor (AhR)-retinoic acid receptor-related orphan nuclear receptor-γt (ROR-γt) complex formation. Here, we investigated whether GLK-induced AhR-ROR-γt complex in T cells is a therapeutic target for human SLE. The population of GLK⁺IL-17A⁺ T cells was enhanced in the peripheral blood

SUBMITTER: Chuang HC 

PROVIDER: S-EPMC6766655 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature