Variations in the proliferative activity of the peripheral retina correlate with postnatal ocular growth in squamate reptiles.

ABSTRACT: The retina is a complex, multilayered tissue responsible for the perception of visual stimuli from the environment. Contrary to mammals, the capacity for postnatal eye growth in fish and amphibians, and to a lower extent in birds, is coordinated with a progenitor population residing in the ciliary marginal zone (CMZ) at the retinal peripheral margin. However, little is known about embryonic retinogenesis and postnatal retinal growth in squamates (lizards, snakes), despite their exceptional array of ecologies and ocular morphologies. Here, we address this gap by performing the first large-scale study assessing both ontogenetic and adult changes in the stem/progenitor activity of the squamate peripheral retina. Our study reveals for the first time that squamates exhibit a source of prolifera

SUBMITTER: Eymann J 

PROVIDER: S-EPMC6766921 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature