Accramycin A, a New Aromatic Polyketide, from the Soil Bacterium, <i>Streptomyces sp.</i> MA37.

ABSTRACT: Drug-like molecules are known to contain many different building blocks with great potential as pharmacophores for drug discovery. The continued search for unique scaffolds in our laboratory led to the isolation of a novel Ghanaian soil bacterium, Streptomyces sp. MA37. This strain produces many bioactive molecules, most of which belong to carbazoles, pyrrolizidines, and fluorinated metabolites. Further probing of the metabolites of MA37 has led to the discovery of a new naphthacene-type aromatic natural product, which we have named accramycin A 1. This molecule was isolated using an HPLC-photodiode array (PDA) guided isolation process and MS/MS molecular networking. The structure of 1 was characterized by detailed analysis of LC-MS, UV, 1D, and 2D NMR data. Pre

SUBMITTER: Maglangit F 

PROVIDER: S-EPMC6767120 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature