Effects of vatinoxan on cardiorespiratory function and gastrointestinal motility during constant-rate medetomidine infusion in standing horses.

ABSTRACT:

Background

Medetomidine suppresses cardiovascular function and reduces gastrointestinal motility in horses mainly through peripheral α₂ -adrenoceptors. Vatinoxan, a peripheral α₂ -antagonist, has been shown experimentally to alleviate the adverse effects of some α₂ -agonists in horses. However, vatinoxan has not been investigated during constant-rate infusion (CRI) of medetomidine in standing horses.

Objectives

To evaluate effects of vatinoxan on cardiovascular function, gastrointestinal motility and on sedation level during CRI of medetomidine.

Study design

Experimental, randomised, blinded, cross-over study.

Methods

Six healthy horses were given medetomidine hydrochloride, 7 μg/kg i.v., without (MED) and with (MED+V) vatinoxan

SUBMITTER: Tapio H 

PROVIDER: S-EPMC6767159 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature