Synthesis, Characterization and Solubility Determination of 6-Phenyl-pyridazin-3(2H)-one in Different Pharmaceutical Solvents.

ABSTRACT: The current research work proposed the solubility data and solution thermodynamic properties of the cardiovascular agent 6-phenylpyridazin-3(2H)-one [PPD] in twelve pharmaceutical solvents at "T = 298.2 K to 318.2 K" and "p = 0.1 MPa". The measured solubilities of PPD were regressed well with "van't Hoff and Apelblat models". The solid phases of pure and equilibrated PPD were characterized using differential scanning calorimetry and powder X-ray differactometry, and the results suggested no transformation of PPD into solvates/hydrates/polymorphs after equilibrium. The solubilities of PPD in a mole fraction at "T = 318.2 K" were noted at a maximum in dimethyl sulfoxide (DMSO, 4.73 × 10-1), followed by polyethylene glycol-400 (PEG-400, 4.12 × 10-1), Transcutol® (3.46 × 10-1), ethyl acetate (

SUBMITTER: Shakeel F 

PROVIDER: S-EPMC6767300 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature