Polyamines Disrupt the KaiABC Oscillator by Inducing Protein Denaturation.

ABSTRACT: Polyamines are positively charged small molecules ubiquitously existing in all living organisms, and they are considered as one kind of the most ancient cellular components. The most common polyamines are spermidine, spermine, and their precursor putrescine generated from ornithine. Polyamines play critical roles in cells by stabilizing chromatin structure, regulating DNA replication, modulating gene expression, etc., and they also affect the structure and function of proteins. A few studies have investigated the impact of polyamines on protein structure and function previously, but no reports have focused on a protein-based biological module with a dedicated function. In this report, we investigated the impact of polyamines (putrescine, spermidine, and spermine) on the cyanobacterial KaiA

SUBMITTER: Li J 

PROVIDER: S-EPMC6767301 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature