Childhood neurodevelopmental difficulties and risk of adolescent depression: the role of irritability.

ABSTRACT:

Background

Children with neurodevelopmental disorders are at increased risk of developing depression. Irritability predicts depression in the general population and is common in children with neurodevelopmental disorders. Thus, it is possible that irritability in children with neurodevelopmental disorders contributes to the link with later depression. This study aimed to (a) examine the association between childhood neurodevelopmental difficulties and adolescent depression and (b) test whether irritability explains this association.

Methods

Children with any neurodevelopmental difficulty at the age of 7-9 (n = 1,697) and a selected, comparison group without any neurodevelopmental difficulty (n = 3,177) were identified from a prospective, UK population-based cohort, the Avon

SUBMITTER: Eyre O 

PROVIDER: S-EPMC6767365 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature