A case-comparison study of pregnant women with mitochondrial disease - what to expect?

ABSTRACT:

Objective

Mitochondrial disease is a disorder of energy metabolism that affects 1 in 4300 adults in the UK. Pregnancy is associated with physiological demands that have implications for energy metabolism. We were interested to know how pregnancy was affected in women with mitochondrial disease, particularly those with the most common pathogenic mutation m.3243A>G.

Design

Retrospective case-comparison study.

Population/setting

Sixty-seven women with genetically confirmed mitochondrial disease from the UK Mitochondrial Diseases Cohort and 69 unaffected women participated.

Methods

Participants answered questionnaires regarding each of their pregnancies. Patients were divided into two groups according to genetic mutation, with those harbouring m.3243A>G comprising

SUBMITTER: Feeney CL 

PROVIDER: S-EPMC6767368 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature