Urogenital symptoms in mitochondrial disease: overlooked and undertreated.

ABSTRACT:

Background and purpose

Bowel symptoms are well documented in mitochondrial disease. However, data concerning other pelvic organs is limited. A large case-control study has therefore been undertaken to determine the presence of lower urinary tract symptoms (LUTS) and sexual dysfunction in adults with genetically confirmed mitochondrial disease.

Methods

Adults with genetically confirmed mitochondrial disease and control subjects were recruited from a specialist mitochondrial clinic. The presence and severity of LUTS and their impact on quality of life, in addition to sexual dysfunction and bowel symptoms, were captured using four validated questionnaires. Subgroup analysis was undertaken in patients harbouring the m.3243A>G MT-TL1 mitochondrial DNA mutation. A subset of patien

SUBMITTER: Poole OV 

PROVIDER: S-EPMC6767393 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature