Characterization of triple-negative breast cancer preclinical models provides functional evidence of metastatic progression.

ABSTRACT: Triple-negative breast cancer (TNBC), an aggressive, metastatic and recurrent breast cancer (BC) subtype, currently suffers from a lack of adequately described spontaneously metastatic preclinical models that faithfully reproduce the clinical scenario. We describe two preclinical spontaneously metastatic TNBC orthotopic murine models for the development of advanced therapeutics: an immunodeficient human MDA-MB-231-Luc model and an immunocompetent mouse 4T1 model. Furthermore, we provide a broad range of multifactorial analysis for both models that could provide relevant information for the development of new therapies and diagnostic tools. Our comparisons uncovered differential growth rates, stromal arrangements and metabolic profiles in primary tumors, and the presence of cancer-associate

SUBMITTER: Arroyo-Crespo JJ 

PROVIDER: S-EPMC6767480 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature