Morphometric MRI profiles of multiple system atrophy variants and implications for differential diagnosis.

ABSTRACT: BACKGROUND:Manual width measurements of the middle cerebellar peduncle on MRI were shown to improve the accuracy of an imaging-guided diagnosis of multiple system atrophy (MSA). Recently, automated volume segmentation algorithms were able to reliably differentiate patients with Parkinson's disease (PD) and the parkinsonian variant of MSA. The objective of the current study was to integrate probabilistic information of the middle cerebellar peduncle into an existing MRI atlas for automated subcortical segmentation and to evaluate the diagnostic properties of the novel atlas for the differential diagnosis of MSA (parkinsonian and cerebellar variant) versus PD. METHODS:Three Tesla MRI scans of 48 healthy individuals were used to establish an automated whole-brain segmentation procedure that i

SUBMITTER: Krismer F 

PROVIDER: S-EPMC6767501 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature