Increase in tympanostomy tube placements despite pneumococcal vaccination, a population-based study.

ABSTRACT:

Aim

The aim was to estimate the impact of the 10-valent pneumococcal vaccine (PHiD-CV) on tympanostomy tube placements (TTP) in children under five years of age in Iceland.

Methods

This population-based observational cohort study followed 11 consecutive birth-cohorts 2005-2015 from birth until their fifth birthday. Population registries were merged using national identification numbers. The risk of TTP was compared between birth-cohorts adjusted for the number of previous otitis media diagnoses and antimicrobial prescriptions. A Cox regression model was applied and the hazard ratio (HR) of TTP was estimated between each birth-cohort and the last vaccine non-eligible birth-cohort. The vaccine impact of PHiD-CV10 on TTP was estimated as 1-HR ×100%.

Results

In total, 51 

SUBMITTER: Eythorsson E 

PROVIDER: S-EPMC6767502 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature