Characterization of inflammatory response in hepatorenal syndrome: Relationship with kidney outcome and survival.

ABSTRACT:

Background

Several lines of evidence indicate that decompensated cirrhosis is characterized by the presence of systemic inflammation. Hepatorenal syndrome (HRS-AKI) is a unique type of renal failure that occurs at late stages of cirrhosis. However, confirmation of the presence and significance of such inflammatory response in HRS-AKI is lacking.

Aim and methods

To characterize the systemic inflammatory response, as estimated by measuring a large number of cytokines, in 161 patients hospitalized for an acute decompensation of cirrhosis: 44 patients without acute kidney injury (AKI), 63 patients with hypovolaemia-induced AKI and 58 patients with HRS-AKI.

Results

HRS-AKI was characterized by an altered cytokine profile compared to the other two groups, particularly IL-6,

SUBMITTER: Sole C 

PROVIDER: S-EPMC6767546 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature