Synchronized activation of striatal direct and indirect pathways underlies the behavior in unilateral dopamine-depleted mice.

ABSTRACT: For more than three decades it has been known, that striatal neurons become hyperactive after the loss of dopamine input, but the involvement of dopamine (DA) D1- or D2-receptor-expressing neurons has only been demonstrated indirectly. By recording neuronal activity using fluorescent calcium indicators in D1 or D2 eGFP-expressing mice, we showed that following dopamine depletion, both types of striatal output neurons are involved in the large increase in neuronal activity generating a characteristic cell assembly of particular neurons that dominate the pattern. When we expressed channelrhodopsin in all the output neurons, light activation in freely moving animals, caused turning like that following dopamine loss. However, if the light stimulation was patterned in pulses the animals circled

SUBMITTER: Jaidar O 

PROVIDER: S-EPMC6767564 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature