MiR-122 Promotes the Development of Colon Cancer by Targeting ALDOA In Vitro.

ABSTRACT: Non-coding RNAs, originally considered junk gene products, have taken center stage in view of their significant involvement in a spectrum of biological processes during human development, thereby offering novel therapeutic targets for improvement of treatment options. Accumulating evidence has demonstrated non-coding RNA dysfunction across various human cancers. In particular, microRNAs have emerged as key regulatory molecules in cancer biology. MicroRNAs are noninvasive, readily accessible biomarkers that can be effectively applied for diagnosis and prognosis of different tumor types, including colon cancer. In this study, we reanalyzed the available data with bioinformatics tools to identify differentially expressed microRNAs in colon cancer cells. The top 3 upregulated microRNAs (miR-10

SUBMITTER: Li H 

PROVIDER: S-EPMC6767722 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature