First-line systemic therapy for advanced gastric cancer: a systematic review and network meta-analysis.

ABSTRACT:

Background

Systemic therapy is the standard treatment against advanced gastric cancer. Fluoropyrimidine plus platinum doublet has been recommended as the preferred first-line strategy. However, there is still a lack of a comprehensive and hierarchical evidence that compares all eligible literature simultaneously.

Methods

Record retrieval was conducted in PubMed, Web of Science, Cochrane Central Register of Controlled Trials, Embase, ASCO, and ESMO meeting library from inception to October 2018. Randomized controlled trials featuring comparisons between different first-line systemic treatments against advanced gastric cancer were eligible. Overall survival was utilized as the primary endpoint. Pairwise and network calculations were based on a random-effects model and the hier

SUBMITTER: Cheng J 

PROVIDER: S-EPMC6767753 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature