Stress-Associated Neurobiological Pathway Linking Socioeconomic Disparities to Cardiovascular Disease.

ABSTRACT:

Background

Lower socioeconomic status (SES) associates with a higher risk of major adverse cardiac events (MACE) via mechanisms that are not well understood.

Objectives

Because psychosocial stress is more prevalent among those with low SES, this study tested the hypothesis that stress-associated neurobiological pathways involving up-regulated inflammation in part mediate the link between lower SES and MACE.

Methods

A total of 509 individuals, median age 55 years (interquartile range: 45 to 66 years), underwent clinically indicated whole-body ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography imaging and met pre-defined inclusion criteria, including absence of known cardiovascular disease or active cancer. Baseline hematopoietic tissue a

SUBMITTER: Tawakol A 

PROVIDER: S-EPMC6767929 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature