Estrogen alpha receptor antagonists for the treatment of breast cancer: a review.

ABSTRACT:

Background

Cancer is at present one of the leading causes of death in the world. It accounts for 13% of deaths occurred worldwide and is continuously rising, with an estimated million of deaths up to 2030. Due to poor availability of prevention, diagnosis and treatment of breast cancer, the rate of mortality is at alarming level globally. In women, hormone-dependent estrogen receptor positive (ER+) breast cancer making up approximately 75% of all breast cancers. Hence, it has drawn the extensive attention of researchers towards the development of effective drugs for the treatment of hormone-dependent breast cancer. Estrogen, a female sex hormone has a vital role in the initiation and progression of breast malignancy. Therefore, estrogen receptor is the central target for the treatm

SUBMITTER: Sharma D 

PROVIDER: S-EPMC6768042 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature