Inherited alterations of TGF beta signaling components in Appalachian cervical cancers.

ABSTRACT:

Purpose

This study examined targeted genomic variants of transforming growth factor beta (TGFB) signaling in Appalachian women. Appalachian women with cervical cancer were compared to healthy Appalachian counterparts to determine whether these polymorphic alleles were over-represented within this high-risk cancer population, and whether lifestyle or environmental factors modified the aggregate genetic risk in these Appalachian women.

Methods

Appalachian women's survey data and blood samples from the Community Awareness, Resources, and Education (CARE) CARE I and CARE II studies (n = 163 invasive cervical cancer cases, 842 controls) were used to assess gene-environment interactions and cancer risk. Polymorphic allele frequencies and socio-behavioral demographic measurements w

SUBMITTER: Knobloch TJ 

PROVIDER: S-EPMC6768402 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature