Reproductive Health in Xeroderma Pigmentosum: Features of Premature Aging.

ABSTRACT:

Objective

To assess the age at menarche and menopause of women with xeroderma pigmentosum, a DNA repair disease with premature aging, in a longitudinal natural history study.

Methods

We conducted a natural history study that reviewed medical records for gynecologic and reproductive health of all female patients with xeroderma pigmentosum aged older than 9 years examined at the National Institutes of Health (NIH). We performed gynecologic and laboratory examinations on a subset of the patients. Women in a second subset, who could not be examined, were interviewed using a questionnaire. Women who were deceased or lost to follow-up formed a third subset.

Results

Sixty females with xeroderma pigmentosum aged older than 9 years (median 29 years, range 10-61 years) were eva

SUBMITTER: Merideth M 

PROVIDER: S-EPMC6768713 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature