Combined nestorone-testosterone gel suppresses serum gonadotropins to concentrations associated with effective hormonal contraception in men.

ABSTRACT:

Background

Novel male-based contraceptives are needed to broaden family planning choices. A progestin, Nestorone^® (Nes) gel, plus a testosterone (T) gel suppresses sperm concentrations to levels associated with effective contraception in normal men. However, administration of two gels on different parts of the body daily is impractical.

Objective

Compare the effectiveness of daily application of a single, combined 8.3 mg Nes-62.5 mg T gel (Nes-T) vs. 62.7 mg T gel to suppress serum FSH and LH concentrations to ≤1.0 IU/L (a threshold associated with suppression of sperm concentrations to ≤1 million and effective contraception) and to compare the pharmacokinetics of serum Nes and T concentrations between the gel groups.

Design

We conducted a 28-day, double-bl

SUBMITTER: Anawalt BD 

PROVIDER: S-EPMC6768743 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature