MAG induces apoptosis in cerebellar granule neurons through p75^NTR demarcating granule layer/white matter boundary.

ABSTRACT: MAG (Myelin-associated glycoprotein) is a type I transmembrane glycoprotein expressed by Schwann cells and oligodendrocytes, that has been implicated in the control of axonal growth in many neuronal populations including cerebellar granule neurons (CGNs). However, it is unclear whether MAG has other functions in central nervous system, in particular, in cerebellar development and patterning. We find that MAG expression in the cerebellum is compartmentalised resulting in increased MAG protein levels in the cerebellar white matter. MAG induces apoptosis in developing CGNs through p75^NTR signalling. Deletion of p75^NTR in vivo reduced the number of apoptotic neurons in cerebellar white matter during development leading to reduction in the size of white matter in the adult

SUBMITTER: Fernandez-Suarez D 

PROVIDER: S-EPMC6768859 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature