Design and Expression of Specific Hybrid Lantibiotics Active Against Pathogenic Clostridium spp.

ABSTRACT: Clostridium difficile has been reported as the most common cause of nosocomial diarrhea (antibiotic-associated diarrhea), resulting in significant morbidity and mortality in hospitalized patients. The resistance of the clostridial spores to antibiotics and their side effects on the gut microbiota are two factors related to the emergence of infection and its relapses. Lantibiotics provide an innovative alternative for cell growth inhibition due to their dual mechanism of action (membrane pore-forming and cell wall synthesis inhibition) and low resistance rate. Based on the fact that bacteriocins are usually active against bacteria closely related to the producer strains, a new dual approach combining genome mining and synthetic biology was performed, by designing new lantibiotics wit

SUBMITTER: Cebrian R 

PROVIDER: S-EPMC6768957 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature