WASp Is Essential for Effector-to-Memory conversion and for Maintenance of CD8⁺T Cell Memory.

ABSTRACT: Wiskott-Aldrich syndrome (WAS) is a rare X-linked primary immunodeficiency characterized by recurrent infections, micro thrombocytopenia, eczema, and a high incidence of autoimmunity and malignancy. A defect in the T cell compartment is thought to be a major cause of immunodeficiency in patients with WAS; However, whether the antigen specific T memory cell is altered has not been extensively studied. Here, we examined the expansion/contraction kinetics of CD8⁺ memory T cells and their maintenance in WASp^-/- mice. The results showed that WAS protein (WASp) is not required for differentiation of CD8⁺ effector T cells; however, CD8⁺ T cells from WASp^-/- mice were hyperactive, resulting in increased cytokine production. The number of CD8

SUBMITTER: Liu Q 

PROVIDER: S-EPMC6769127 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature