Global transcriptional regulation of STAT3- and MYC-mediated sepsis-induced ARDS.

ABSTRACT:

Background

In recent years, sepsis-induced acute respiratory distress syndrome (ARDS) has remained a major clinical challenge for patients in intensive care units. While some progress has been reported over the years, the pathogenesis of ARDS still needs to be further expounded.

Methods

In the present study, gene set enrichment analysis, differentially expressed genes analysis, short time-series expression miner, protein-protein interaction (PPI) networks, module analysis, hypergeometric test, and functional enrichment analysis were performed in whole blood gene expression profiles of sepsis and induced-sepsis ARDS to explore the molecular mechanism of sepsis-induced ARDS.

Results

Further dysregulated genes in the process evolving from healthy control through sepsis t

SUBMITTER: Zhang J 

PROVIDER: S-EPMC6769203 | biostudies-literature | 2019 Jan-Dec

REPOSITORIES: biostudies-literature