Do bevacizumab solutions interact with silicone or polyurethane catheters during an infusion through implantable venous access ports?

ABSTRACT: This work aims to evaluate the possible impact of interactions between bevacizumab solutions and an implantable port equipped with a silicone or a polyurethane catheter after infusion through a complete infusion set-up in simulated use conditions. Physico-chemical and structural stability of bevacizumab solution was assessed by visual examination, subvisible particles counting, dynamic light scattering, size exclusion chromatography and ion exchange chromatography. Mechanical properties of the catheters were evaluated by measuring Shore A hardness, strain at break, strain at stress and Young's modulus. The physico-chemical surface state of the catheters was assessed by FTIR-ATR spectroscopy, scanning electron microscopy (SEM) and by water contact angle measurement. The analysis of the beva

SUBMITTER: Tokhadze N 

PROVIDER: S-EPMC6769320 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature