Circulating vitamin E and cardiometabolic measures: a Mendelian randomization analysis.

ABSTRACT: Although a large body of literature reported that high intake of vitamin E played a possible role in reducing risk of cardiometabolic diseases, conflicting results were also found in some observational studies due to confounding factors. Hence, we used a Mendelian randomization study as an alternative way to examine the causality between circulating vitamin E and cardiometabolic diseases. Summary-level data were extracted from consortia and three single nucleotide polymorphisms were used as instrumental variables. Our study showed that a one-SD increase in circulating vitamin E levels was causally associated with an increased risk of coronary artery disease [odds ratio (OR) 3.16 (95%CI 1.74, 5.73); p = 1.91 × 10^-3] at the Bonferroni-adjusted level of significance (p

SUBMITTER: Fan C 

PROVIDER: S-EPMC6769411 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature