Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease.

ABSTRACT: Systematic epistasis analyses in multifactorial disorders are an important step to better characterize complex genetic risk structures. We conducted a hypothesis-free sex-stratified genome-wide screening for epistasis contributing to Alzheimer's disease (AD) susceptibility. We identified a statistical epistasis signal between the single nucleotide polymorphisms rs3733980 and rs7175766 that was associated with AD in males (genome-wide significant p_{Bonferroni-corrected}=0.0165). This signal pointed toward the genes WW and C2 domain containing 1, aka KIBRA; 5q34 and TLN2 (talin 2; 15q22.2). Gene-based meta-analysis in 3 independent consortium data sets confirmed the identified interaction: the most significant (p_{meta-Bonferroni-corrected}=9.02*10^-3) was for the

SUBMITTER: Gusareva ES 

PROVIDER: S-EPMC6769421 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature