Transcriptional Regulation of the Bovine Fatty Acid Transport Protein 1 Gene by Kruppel-Like Factors 15.

ABSTRACT: Oleic acid is a major monounsaturated fatty acid, which accounts for about 33% of the fatty acid content in beef and is considered to have the least negative effect on serum cholesterol levels. Fatty acid transport protein 1 (FATP1), an integral membrane protein that facilitates long-chain fatty acid (LCFA) influx, is involved in the genetic network for oleic acid synthesis in beef. Its expression exhibits significant positive correlations with intramuscular fat (IMF) content in the longissimus thoracis. However, the expression mechanism of SLC27A1 or FATP1 is still unclear. To elucidate the molecular mechanisms involved in bovine SLC27A1 regulation, we cloned and characterized the promoter region of SLC27A1. By applying 5'-rapid amplification of cDNA end analys

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC6769441 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature